Endoscopy Trial

PYLOTUM > Projects > Endoscopy Trial

In addition to the “Large-Linqu-Trial” we initiated an endoscopic screening study in 2019. With already 2200 volunteer residents from Linqu County enrolled, we aim to follow up every 3 years for up to 10 years a total of 10 000 volunteers. Gastric pathology will be assessed using a standardized biopsy mapping protocol. The goal of this study is to determine the molecular and histopathological features of the gastric mucosa with and without H. pylori therapy under endoscopic surveillance. Molecular sub-studies will be performed to prospectively assess the individual risk for gastric cancer and for certain pre-neoplastic lesions by blood and tissue markers. Based on this, a risk score (also including other risk factors like age, gender, and smoking) will be established.

This study is an important next step after the ongoing “Large-Linqu-Trial”, addressing histopathologic, serologic and molecular biomarkers for assessment of gastric cancer risk.

Since health resources and antibiotic resistance currently do not allow a mass antibiotic treatment, it is of high clinical and economic impact to identify those individuals that are at high risk and would profit from preventive eradication and require endoscopic surveillance. If the study should confirm the assumed preventive effect of H. pylori treatment on development or progression of gastric precancerous lesions, anti-microbial treatment should be made available for the H. pylori positive persons who are at particular risk of developing gastric cancer, not only in Linqu County. The identification of biomarkers is an important aspect to improve early detection, especially in countries where prevalence is high and gastroscopic screening is not readily available for the broad population.

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Contact Information

Professor Kai-feng Pan

Department of Cancer Epidemiology, Peking University School of Oncology (PUSO)
Peking University Cancer Hospital & Institute

No.52 Fu-cheng Road, Haidian District, Beijing 100142, China


Funded by: Federal Ministry of Education and Research (BMBF)  |  Ministry of Science and Technology of the People’s Republic of China  |  Beijing Municipal Science and Technology Commission